Hillsboro is located on the east side of Missouri, 35 miles southwest of St. Louis.
With nearby communities such as De Soto, Cedar Hill, Festus, Crystal City and several others within approximately 10 miles, Hillsboro has many neighbors, each with a unique array of dining, shopping and entertainment amenities.
Traveling to and from Hillsboro is as simple as hopping on MO-21. The expressway bisects Hillsboro and leads to easy links to Missouri's main thoroughfares, as well as the St. Louis beltway. I-44, I-55, I-270, I-64, I-70 and many others are close enough to make Hillsboro a convenient place to reach from any direction.