Poplar Bluff can be reached by three U.S. highways, two Missouri highways and a complete network of local streets.
Southeast Missouri Transportation Service is a nongovernmental, nonprofit organization that provides door-to-door service to riders of all ages throughout south central and southeastern Missouri.
Poplar Bluff also has Amtrak and Greyhound stations, which extend service throughout the nation.
Poplar Bluff Municipal Airport offers air charters, pilot services and flight instruction. They provide a trip quote in minutes and make all flight arrangements, including accommodations upon landing.